Peadar Noone
Associate Professor of Medicine &
Medical Director of the Lung Transplant

 

Degrees
     MB, Bch, BAO:
         (1983) U. College Galway Medical
             School, Ireland

     MD [Doctorate Degree]:
        (1997) U. College Galway
          Medical School, Ireland
     Residency/Fellowship:
         (1983-89) Univ. Hospitals in
         Galway & Dublin, Ireland
         Tufts University, Boston, MA
         UNC, Chapel Hill,   NC

Peadar Noone

 

Phone: 919-966-2531
Email:   pnoone@med.unc.edu

 

Research Interests:

The correlations between genetic disease and disease expression at a cell biologic and organ level, particularly as pertains to airways disease and other related diseases.

  • Airway host defence, disorders of ciliary structure/function.
  • Drug delivery to the lung.
  • Gene therapy, and other novel therapies for CF.
  • Genetics of airways diseases.
  • Clinical Interests:

  • General internal medicine & General Pulmonary Medicine
  • Lung diseases associated with genetic abnormalities – cystic fibrosis, primary ciliary dyskinesia, bronchiectasis.
  • Infectious diseases of the lung – tuberculosis and non-tuberculous infections.
  • Lung Transplant Medicine

  • Recent Publications:

    Olbrich H, Haffner K, Kispert A, Volkel A, Volz A, Sasmaz G, Reinhardt R, Hennig S, Lehrach H, Konietzko N, Zariwala M, Noone PG, Knowles M, Mitchison HM, Meeks M, Chung EM, Hildebrandt F, Sudbrak R, Omran H. Mutations in DNAH5 Cause Primary Ciliary Dyskinesia and Randomization of Left-Right Asymmetry. National Genet. 2002; 30(2):143-4.

    Noone PG, Zariwala M, Sannuti A, Minnix S, Leigh MW, Carson J, Knowles MR. Chest. 2002;121(3 Suppl):97S.

    Cohn JA, Noone PG, Jowell PS. Idiopathic Pancreatitis Related to CFTR: Complex Inheritance and Identification of a Modifier Gene. J Investig Med. 2002; 50(5):247S-255S.

    Noone PG, Egan TM. Cystic Fibrosis: When to Refer for Lung Transplantation-Is The Answer Clear? Am J Respir Crit Care Med. 2002; 166(12):1531 - 2.

    Kispert A, Petry M, Olbrich H, Volz A, Ketelsen UP, Horvath J, Melkaoui R, Omran H, Zariwala M, Noone PG, Knowles M. Genotype-phenotype Correlations in PCD Patients Carrying DNAH5 Mutations. Thorax. 2003:58(6):522-4.

    Zariwala M, O'Neal WK, Noone PG, Leigh MW, Knowles MR, Ostrowski LE. Investigation of the Possible Role of a Novel Gene, DPCD, in Primary Ciliary Dyskinesia. Am J Respir Cell Mol Biol. 2004; 30(4):428-34.

    Noone PG, Leigh MW, Sannuti A, Minnix SL, Carson JL, Hazucha M, Zaiwala MA, Knowles MR. Primary Ciliary Dyskinesia: Diagnostic and Phenotypic Features. Am J Respir Crit Care Med. 2004; 169(4):459-67.

    Standaert TA, Boitano L, Emerson J, Milgram LJ, Konstan MW, Hunter J, Berclaz PY, Brass L, Zeitlin PL, Hammond K, Davies Z, Foy C, Noone PG, Knowles MR. Pediatr Pulmonol. 2004; 37(5):385-92.

    Noone PG, Southern KW. Unravelling Salt Tranport in Cystic Fibrosis. Thorax. 2004; 59(11):916-7.

    TEXTBOOK CHAPTERS / THESIS :

    Noone PG, Sicilian L. Interstitial lung disease. In: Difficult Diagnosis 11. Taylor Ed. WB Saunders, Philadelphia 1992; 266-274.

    Noone PG. MD thesis: Pharmacokinetic and efficacy studies of new treatments for cystic fibrosis and primary ciliary dyskinesia 1997, NUIG.


    Knowles MR, Noone PG, Bennett WD, Boucher RC. Mucociliary and cough clearance: Role of ion transport and the P2Y2 receptor-mediated system. In: Cilia, mucus, and mucociliary interactions. Baum G., ed. Marcel Dekker, Inc., New York 1998: 307-315.

    Noone PG, Bresnihan,B. Rheumatologic disease in adults with CF. In : Cystic fibrosis in adults. Yankaskas, JR, Knowles, MR, eds. Lippincott-Raven Publishers, Philadelphia, 1999; pages 439-447.

    Noone PG, Knowles MR. Standard Therapy of Cystic Fibrosis Lung Disease. In : Cystic fibrosis in adults. Yankaskas, JR, Knowles, MR, eds. Lippincott-Raven Publishers, Philadelphia, 1999; pages 145-173.

    Regulation of mucociliary clearance by purinergic receptors. Bennett WD, Noone PG, Knowles, MR, Boucher, RC. In Cilia and Mucus: From development to respiratory defense, ed Salathe M, Marcel Dekker, Inc. NY, 2001, pp 347-360.

    Section editor: Pulmonary Diseases. In: Runge M, Patterson C, eds. Principles of Molecular Medicine, 2nd. Totowa, New Jersey: Humana Press, 2005.

    Noone PG, Zairwala M, Knowles M. Primary Ciliary Dyskinesia. In Runge M, Patterson C, eds. Principles of Molecular Medicine, 2nd. Totowa, New Jersey: Humana Press, 2005.

     


    UNC - Chapel Hill UNC - School of Medicine

    Clinical Contact        
    Phone: (919) 966-2531
    Fax: (919) 966-7013
    130 Mason Farm Rd.
    CB #7020
    The Univ. of North Carolina
    Chapel Hill, NC 27599-7020

    Research Contact      
    Phone: (919) 966-1077
    Fax: (919) 966-5178
    7011 Thurston-Bowles Bldg.
    CB #7248
    The Univ. of North Carolina
    Chapel Hill, NC 27599-7248